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Laboratory Scientist

Educational Resources

There have been a number of studies supporting the effectiveness of using amniotic membranes in various types of medical procedures.    

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Implantation of amniotic membrane to reduce postlaminectomy epidural adhesions

Hulren T and Honbin F. (2009) Eur Spine J, 18(8):1202-1212, doi:10.1007/s00586-09-1013-x.

Postlaminectomy epidural adhesion is implicated as a main cause of “failed back surgery syndrome” and associated with increased risk of complications during revision surgery. Various materials acting as mechanical barriers to reduce fibroblasts infiltration into epidural space have met with limited success. In present research, amniotic membrane (AM) was studied to investigate its effects on reducing epidural scar adhesion after laminectomy in a canine model. 

Kuriu Y and et al. (2009) Hepatogastroenterology, 56(93): 1064-8.

Adhesions following intraperitoneal surgery are frequent causes of small bowel obstruction. Attempts to prevent postoperative adhesions have mostly proven disappointing clinically. Currently used by ophthalmologists in ocular surface disorders, amniotic membrane transplantation can reduce inflammation and promote re-epithelization. We used amniotic membrane for facilitating peritoneal regeneration and prevention of adhesions with surgical trauma.

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McJunkin T, Lynch P, Deer TR, Anderson J and Desal R. (2012) Pain Medicine News Special Edition, McMahon Publishing.

Regenerative medicine, where the body regenerates or rebuilds itself, is a relatively new and rapidly evolving front in the field of interventional pain management. Although stem cell therapy has garnered much of the attention over the past several decades, multiple other regenerative medicine modalities also have caught the public’s attention. As experts in our field, we should be ascertaining if and when to offer these treatments to our patients.

Mligiliche N and et al. (2002) Journal of Biomedical Materials Research, 63(5):591-600. DOI:10.1002/jbm. 10349.

The human amnion consists of the epithelial cell layer and underlying connective tissue. After removing the epithelial cells, the resulting acellular connective tissue matrix was manufactured into thin dry sheets called amnion matrix sheets. The sheets were further processed into tubes, amnion matrix tubes (AMTs), of varying diameters, with the walls of varying numbers of amnion matrix sheets with or without a gelatin coating

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Vipul R. Patel*, Srinivas Samavedi, Anthony S. Bates, Anup Kumar, Rafael Coelho, Bernardo Rocco, Kenneth Palmer. (2015)

We present a propensity-matched analysis of patients undergoing placement of dehydrated human amnion/chorion membrane (dHACM) around the neurovascular bundle (NVB) during nerve-sparing (NS) robot-assisted laparoscopic prostatectomy (RARP). From March 2013 to July 2014, 58 patients who were preoperatively potent (Sexual Health Inventory for Men [SHIM] score >19) and continent (no pads) underwent full NS RARP. Postoperative outcomes were analyzed between propensity-matched graft and no-graft groups, including time to return to continence, potency, and biochemical recurrence.

N.G. Fairbaim*, M.A. Randolph, R.W. Redmond. (2014)

Since the early 1900s, human amnion has been applied to a wide variety of clinical scenarios including burns, chronic ulcers, dural defects, intra-abdominal adhesions, peritoneal reconstruction, genital reconstruction, hip arthroplastytendon repairnerve repairmicrovascular reconstruction, corneal repair, intra-oral reconstruction and reconstruction of the nasal lining and tympanic membrane. Amnion epithelial and mesenchymal cells have been shown to contain a variety of regulatory mediators that result in the promotion of cellular proliferation, differentiation and epithelialisation and the inhibition of fibrosis, immune rejection, inflammation and bacterial invasion.

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B.R. Subach and A.G. Copay. (2014)

Background Context: Products that can reduce development of epidural fibrosis may reduce risk for ongoing pain associated with development of scar tissue and make subsequent epidural reexploration easier. Purpose: To evaluate the use of dehydrated human amnion/chorion membrane (dHACM) on the formation of soft tissue scarring in the epidural space. Study Design. Case series. Patient Sample: Five patients having transforaminal lumbar interbody lumbar fusion (TLIF) with posterior instrumentation and implantation of dHACM in the epidural space and subsequent epidural reexploration. Outcome Measures: Degree of scar tissue adjacent to the epidural space at reexploration. Intraoperative and postoperative complications related to dHACM and patient reported outcomes.

Amer MI, Adb-El-Maeboud KH, Abdelfatah I, Salama FA, Abdallah AS. (2010) Sep-Oct; 17(5):605-11. DOI:10.1016/j.jmig.2010.03.019. Epub 2010 Jun 23.

Study objective: To estimate the efficacy of fresh and dried amnion graft after hysteroscopic lysis of severe intrauterine adhesions in decreasing its recurrence and encouraging endometrial regeneration. Design: Pilot prospective randomized comparative study (Canadian Task Force classification I). Setting: Ain Shams Medical School, Cairo, Egypt. Patients: Forty-five patients with severe intrauterine adhesions. Primary symptom was infertility with or without menstrual disorders such as amenorrhea or hypomenorrhea.

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